Document Detail


Cytokines and HCV-related disorders.
MedLine Citation:
PMID:  22611419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases--mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes--are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process.
Authors:
Poupak Fallahi; Clodoveo Ferri; Silvia Martina Ferrari; Alda Corrado; Domenico Sansonno; Alessandro Antonelli
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-05-07
Journal Detail:
Title:  Clinical & developmental immunology     Volume:  2012     ISSN:  1740-2530     ISO Abbreviation:  Clin. Dev. Immunol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-09-07     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  101183692     Medline TA:  Clin Dev Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  468107     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity
Cytokines / immunology*
Hepacivirus / immunology*
Hepatitis C / complications,  drug therapy,  immunology*
Humans
Immune Evasion
Immunity
Interferon-alpha / therapeutic use
Liver Cirrhosis / etiology,  immunology*,  prevention & control
Th1-Th2 Balance
Viral Load / drug effects
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interferon-alpha
Comments/Corrections

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