| Cytokines and HCV-related disorders. | |
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MedLine Citation:
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PMID: 22611419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis. The most important systemic HCV-related extrahepatic diseases--mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes--are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process. |
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Authors:
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Poupak Fallahi; Clodoveo Ferri; Silvia Martina Ferrari; Alda Corrado; Domenico Sansonno; Alessandro Antonelli |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-05-07 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2012 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-05-21 Completed Date: 2012-09-07 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: Egypt |
Other Details:
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Languages: eng Pagination: 468107 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmunity Cytokines / immunology* Hepacivirus / immunology* Hepatitis C / complications, drug therapy, immunology* Humans Immune Evasion Immunity Interferon-alpha / therapeutic use Liver Cirrhosis / etiology, immunology*, prevention & control Th1-Th2 Balance Viral Load / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interferon-alpha |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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