Document Detail


Cytokine targeting in psoriasis and psoriatic arthritis: beyond TNFalpha.
MedLine Citation:
PMID:  16329645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Targeting TNFalpha provided proof of concept for the role of pro-inflammatory cytokines in promoting cutaneous inflammation, particularly psoriasis. Recent studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets. IL-15 is an innate response cytokine that activates leukocyte subsets via binding to its unique IL-15Ralpha and shared beta and gamma chain receptors. IL-15 promotes T cell memory and sustains local T cell activation, in part via prevention of apoptosis and mediates activation of monocytes, neutrophils and NK cells. IL-15 is up-regulated in psoriatic skin and psoriatic arthritis synovium. IL-15 blockade in a murine model of psoriasis led to marked suppression of typical psoriatic skin features. Clinical intervention in other chronic inflammatory disease states is now ongoing with encouraging early efficacy, raising the possibility for the first time of targeting this novel inflammatory moiety in psoriasis.
Authors:
I B MclInnes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ernst Schering Research Foundation workshop     Volume:  -     ISSN:  0947-6075     ISO Abbreviation:  Ernst Schering Res. Found. Workshop     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422786     Medline TA:  Ernst Schering Res Found Workshop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  29-44     Citation Subset:  IM    
Affiliation:
Division of Immunology, Infection and Inflammation, University of Glasgow, Centre for Rheumatic Diseases, Glasgow, Scotland. i.b.mcinnes@climed.gla.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / therapeutic use
Arthritis, Psoriatic / drug therapy,  immunology*
Autoimmunity / physiology
Cytokines / antagonists & inhibitors,  immunology*
Humans
Inflammation / drug therapy,  immunology
Interleukin-15 / antagonists & inhibitors,  immunology*
Psoriasis / drug therapy,  immunology*
Tumor Necrosis Factor-alpha / immunology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Interleukin-15; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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