| Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. | |
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MedLine Citation:
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PMID: 21518857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue- and adult-specific expression of RNAi and dominant-negative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms. |
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Authors:
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Tijana Copf; Valérie Goguel; Aurélie Lampin-Saint-Amaux; Niki Scaplehorn; Thomas Preat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-25 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-11 Completed Date: 2011-07-15 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8059-64 Citation Subset: IM |
Affiliation:
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Genes and Dynamics of Memory Systems, Neurobiology Unit, École Supérieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Base Sequence Cytokines / antagonists & inhibitors, genetics, physiology* DNA Primers / genetics Drosophila / genetics, physiology* Drosophila Proteins / antagonists & inhibitors, genetics, physiology* Gene Knockdown Techniques Genes, Insect Janus Kinases / antagonists & inhibitors, genetics, physiology* Memory, Long-Term / physiology* Mushroom Bodies / physiology RNA Interference Receptors, Interleukin / antagonists & inhibitors, genetics, physiology STAT Transcription Factors / antagonists & inhibitors, genetics, physiology* Signal Transduction / genetics, physiology Smell / physiology Transcription Factors / antagonists & inhibitors, genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/DNA Primers; 0/Drosophila Proteins; 0/Receptors, Interleukin; 0/STAT Transcription Factors; 0/Stat92E protein, Drosophila; 0/Transcription Factors; 0/domeless protein, Drosophila; 0/os protein, Drosophila; EC 2.7.1.112/hopscotch protein, Drosophila; EC 2.7.10.2/Janus Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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