Document Detail

Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response.
MedLine Citation:
PMID:  17950614     Owner:  NLM     Status:  MEDLINE    
Exercise and physical strenuous activity have been demonstrated to increase the serum TNF-alpha and IL-6. Regular physical training is expected to attenuate such a response. This study was undertaken to understand the impact of regular exercise training on IL-6 and TNF-alpha in athletes and non-athletes. Ten athletes, who have been on regular training for the past 6 months, and 10 age- and sex-matched subjects (non-athlete group) who had no practice of regular exercise, were recruited. Both were subjected to undergo the same frequency level of strenuous exercise. Blood samples were collected; one before strenuous exercise and the other after the exercise. Plasma cytokines, IL-6 and TNF-alpha, were estimated using Sandwich ELISA method. All participants in the study were male with the athletes' age being 18.00+/-1.3years (mean+/-SD) and the non-athletes were aged 20.00+/-0.6years (mean+/-SD). Majority of the athletes and non-athletes demonstrated a rise in IL-6 and a fall in TNF-alpha levels. Further, the athletes showed a lesser magnitude of change in the cytokine levels following a longer duration of exercise than non-athletes. Athletes appear to have an attenuated cytokine response. Regular physical training has been demonstrated to attenuate the immune response to exercise in either direction.
Rohit Gokhale; S Chandrashekara; K C Vasanthakumar
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Publication Detail:
Type:  Journal Article     Date:  2007-10-22
Journal Detail:
Title:  Cytokine     Volume:  40     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Department of Immunology, MS Ramiah Medical College, Bangalore, India.
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MeSH Terms
Adaptation, Physiological / physiology
Exercise / physiology*
Interleukin-6 / blood*
Time Factors
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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