| Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. | |
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MedLine Citation:
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PMID: 17950614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise and physical strenuous activity have been demonstrated to increase the serum TNF-alpha and IL-6. Regular physical training is expected to attenuate such a response. This study was undertaken to understand the impact of regular exercise training on IL-6 and TNF-alpha in athletes and non-athletes. Ten athletes, who have been on regular training for the past 6 months, and 10 age- and sex-matched subjects (non-athlete group) who had no practice of regular exercise, were recruited. Both were subjected to undergo the same frequency level of strenuous exercise. Blood samples were collected; one before strenuous exercise and the other after the exercise. Plasma cytokines, IL-6 and TNF-alpha, were estimated using Sandwich ELISA method. All participants in the study were male with the athletes' age being 18.00+/-1.3years (mean+/-SD) and the non-athletes were aged 20.00+/-0.6years (mean+/-SD). Majority of the athletes and non-athletes demonstrated a rise in IL-6 and a fall in TNF-alpha levels. Further, the athletes showed a lesser magnitude of change in the cytokine levels following a longer duration of exercise than non-athletes. Athletes appear to have an attenuated cytokine response. Regular physical training has been demonstrated to attenuate the immune response to exercise in either direction. |
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Authors:
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Rohit Gokhale; S Chandrashekara; K C Vasanthakumar |
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Publication Detail:
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Type: Journal Article Date: 2007-10-22 |
Journal Detail:
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Title: Cytokine Volume: 40 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Affiliation:
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Department of Immunology, MS Ramiah Medical College, Bangalore, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology Adolescent Adult Exercise / physiology* Humans Interleukin-6 / blood* Male Time Factors Tumor Necrosis Factor-alpha / blood* |
| Chemical | |
Reg. No./Substance:
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0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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