| Cytokine release, small airway injury, and parenchymal damage during mechanical ventilation in normal open-chest rats. | |
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MedLine Citation:
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PMID: 17962576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lung morpho-functional alterations and inflammatory response to various types of mechanical ventilation (MV) have been assessed in normal, anesthetized, open-chest rats. Measurements were taken during protective MV [tidal volume (Vt) = 8 ml/kg; positive end-expiratory pressure (PEEP) = 2.6 cmH(2)O] before and after a 2- to 2.5-h period of ventilation on PEEP (control group), zero EEP without (ZEEP group) or with administration of dioctylsodiumsulfosuccinate (ZEEP-DOSS group), on negative EEP (NEEP group), or with large Vt (26 ml/kg) on PEEP (Hi-Vt group). No change in lung mechanics occurred in the Control group. Relative to the initial period of MV on PEEP, airway resistance increased by 33 +/- 4, 49 +/- 9, 573 +/- 84, and 13 +/- 4%, and quasi-static elastance by 19 +/- 3, 35 +/- 7, 248 +/- 12, and 20 +/- 3% in the ZEEP, NEEP, ZEEP-DOSS, and Hi-Vt groups. Relative to Control, all groups ventilated from low lung volumes exhibited histologic signs of bronchiolar injury, more marked in the NEEP and ZEEP-DOSS groups. Parenchymal and vascular injury occurred in the ZEEP-DOSS and Hi-Vt groups. Pro-inflammatory cytokine concentration in the bronchoalveolar lavage fluid (BALF) was similar in the Control and ZEEP group, but increased in all other groups, and higher in the ZEEP-DOSS and Hi-Vt groups. Interrupter resistance was correlated with indexes of bronchiolar damage, and cytokine levels with vascular-alveolar damage, as indexed by lung wet-to-dry ratio. Hence, protective MV from resting lung volume causes mechanical alterations and small airway injury, but no cytokine release, which seems mainly related to stress-related damage of endothelial-alveolar cells. Enhanced small airway epithelial damage with induced surfactant dysfunction or MV on NEEP can, however, contribute to cytokine production. |
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Authors:
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Edgardo D'Angelo; Antonia Koutsoukou; Patrizia Della Valle; Guendalina Gentile; Matteo Pecchiari |
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Publication Detail:
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Type: Journal Article Date: 2007-10-25 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-16 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 41-9 Citation Subset: IM |
Affiliation:
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Istituto di Fisiologia Umana I, Milan, Italy. edgardo.dangelo@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Animals Bronchoalveolar Lavage Fluid / chemistry Carbon Dioxide / blood Cytokines / metabolism* Detergents / pharmacology Drug Combinations Hydrogen-Ion Concentration Isatin / analogs & derivatives, pharmacology Lung / drug effects, metabolism, pathology, physiopathology* Lung Compliance Lung Diseases / etiology*, metabolism, pathology, physiopathology Male Oxygen / blood Positive-Pressure Respiration / adverse effects* Pulmonary Edema / etiology, metabolism, physiopathology Pyridines / pharmacology Rats Rats, Sprague-Dawley Respiratory Mechanics* Succinates / pharmacology Tidal Volume Up-Regulation Ventilators, Negative-Pressure / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Detergents; 0/Drug Combinations; 0/Pyridines; 0/Succinates; 124-38-9/Carbon Dioxide; 18869-73-3/laxagetten 4,4'-diacetoxydiphenylpyridylemethane; 7782-44-7/Oxygen; 91-56-5/Isatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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