Document Detail


Cytokine regulation of granuloma formation in schistosomiasis.
MedLine Citation:
PMID:  7495514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granuloma induced by the schistosome egg is an inflammatory reaction that is tightly controlled by the interaction of T-helper cell type 1 (Th1) and Th2 cytokines produced locally. Studies focussing on the immunoregulation of the response have yielded numerous insights into the cytokine cascade that controls the formation of the lesions. It is clear from current data that the Th2 cytokines play a primary role in granuloma formation, whereas the Th1-associated lymphokine interferon-gamma acts as an endogenous downregulator of the response. Through recent advances, it may now be possible to design effective cytokine-based vaccination strategies that will suppress the tissue pathology associated with this helminth infection.
Authors:
T A Wynn; A W Cheever
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in immunology     Volume:  7     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  IM    
Affiliation:
Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / physiology*
Granuloma / etiology*
Schistosomiasis / complications*
Chemical
Reg. No./Substance:
0/Cytokines

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