Document Detail

Cytokine regulation of granuloma formation in schistosomiasis.
MedLine Citation:
PMID:  7495514     Owner:  NLM     Status:  MEDLINE    
Granuloma induced by the schistosome egg is an inflammatory reaction that is tightly controlled by the interaction of T-helper cell type 1 (Th1) and Th2 cytokines produced locally. Studies focussing on the immunoregulation of the response have yielded numerous insights into the cytokine cascade that controls the formation of the lesions. It is clear from current data that the Th2 cytokines play a primary role in granuloma formation, whereas the Th1-associated lymphokine interferon-gamma acts as an endogenous downregulator of the response. Through recent advances, it may now be possible to design effective cytokine-based vaccination strategies that will suppress the tissue pathology associated with this helminth infection.
T A Wynn; A W Cheever
Related Documents :
11983254 - The critical role of cd4(+) t-cell help in immunity to hiv.
18422734 - T helper 1 (th1)/th2 cytokine expression shift of peripheral blood cd4+ and cd8+ t cell...
21255694 - Triptolide and its expanding multiple pharmacological functions.
11810184 - Cytokine and cytokine receptor mrna expression in human glioblastomas: evidence of th1,...
23935424 - Reinforcement learning based artificial immune classifier.
14643884 - Protein kinase c epsilon: a new target to control inflammation and immune-mediated diso...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in immunology     Volume:  7     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  IM    
Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cytokines / physiology*
Granuloma / etiology*
Schistosomiasis / complications*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Induction of Th2 responses in infectious diseases.
Next Document:  The protective immune response to Mycobacterium tuberculosis.