| Cytokine regulation of granuloma formation in schistosomiasis. | |
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MedLine Citation:
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PMID: 7495514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granuloma induced by the schistosome egg is an inflammatory reaction that is tightly controlled by the interaction of T-helper cell type 1 (Th1) and Th2 cytokines produced locally. Studies focussing on the immunoregulation of the response have yielded numerous insights into the cytokine cascade that controls the formation of the lesions. It is clear from current data that the Th2 cytokines play a primary role in granuloma formation, whereas the Th1-associated lymphokine interferon-gamma acts as an endogenous downregulator of the response. Through recent advances, it may now be possible to design effective cytokine-based vaccination strategies that will suppress the tissue pathology associated with this helminth infection. |
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Authors:
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T A Wynn; A W Cheever |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in immunology Volume: 7 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-01-16 Completed Date: 1996-01-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 505-11 Citation Subset: IM |
Affiliation:
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Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / physiology* Granuloma / etiology* Schistosomiasis / complications* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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