Document Detail

Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss.
MedLine Citation:
PMID:  11438378     Owner:  NLM     Status:  MEDLINE    
Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology of which is unknown in at least 40% of cases. Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-alpha and interferon-gamma) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating blood lymphocytes isolated from these patients when compared with controls. The reasons for this are unclear. The production of these cytokines are partly under genetic control. This study investigated whether polymorphisms in these three cytokine genes known to be associated with either high or low production, are associated with idiopathic RPL. No association was found. It may be that genetic factors are not a major determinant of cytokine production during pregnancy, or alternatively it may be that the observed differences in cytokine production by peripheral lymphocytes do not accurately indicate what is occurring at the local maternofoetal interface during successful and abortive pregnancies.
S J Babbage; P D Arkwright; G S Vince; C Perrey; V Pravica; S Quenby; M Bates; I V Hutchinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  51     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Immunology Research Group, School of Biological Sciences, University of Manchester, Stopford Building, M13 9PT, Manchester, UK.
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MeSH Terms
Abortion, Habitual / genetics*
Cytokines / genetics*
Genetic Predisposition to Disease
Interferon-gamma / genetics
Interleukin-10 / genetics
Middle Aged
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Tumor Necrosis Factor-alpha / genetics
Reg. No./Substance:
0/Cytokines; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

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