Document Detail


Cytokine profiles in drug-naive schizophrenic patients.
MedLine Citation:
PMID:  11278147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-gamma] in drug-free (n=26) and drug-naive (n=7) schizophrenic patients and in healthy controls (n=33). Production of IL-2 and INF-gamma was significantly higher (respectively P=0.021 and P=0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.
Authors:
C L Cazzullo; E Sacchetti; A Galluzzo; A Panariello; F Colombo; A Zagliani; M Clerici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schizophrenia research     Volume:  47     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-06-28     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Affiliation:
Association for Research on Schizophrenia (A.R.S.), Fondazione Legrenzi, via Francesco Tamagno 5, 20124 Milan, Italy. arsmilano@tiscalinet.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Cytokines / blood*,  immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Schizophrenia / immunology*
Chemical
Reg. No./Substance:
0/Cytokines

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