Document Detail

Cytokine profile in collagen-induced arthritis: differences between syngeneic and allogeneic pregnancy.
MedLine Citation:
PMID:  18516708     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA). METHODS: Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period. RESULTS: In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery. CONCLUSIONS: Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).
D Almeida González; A Cabrera de León; C Vázquez Moncholi; B Brito Díaz; M C Rodríguez Pérez; A Aguirre-Jaime; S Domínguez Coello; A González Hernández
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  57     ISSN:  1023-3830     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  266-71     Citation Subset:  IM    
Research Unit, Hospital de La Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain.
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MeSH Terms
Arthritis, Experimental / blood,  immunology*,  pathology
Cytokines / blood,  immunology*
Disease Models, Animal
Mice, Inbred Strains / blood,  immunology*
Pregnancy, Animal / blood,  immunology*
Reg. No./Substance:

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