| Cytokine profile of bronchoalveolar lavage fluid in patients with combined pulmonary fibrosis and emphysema. | |
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MedLine Citation:
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PMID: 22515655 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARY AT A GLANCE: The levels of various inflammatory mediators in bronchoalveolar lavage fluid were measured in patients with combined pulmonary fibrosis and emphysema. In patients with pulmonary fibrosis, elevated concentrations of CXC chemokines (CXCL5 and CXCL8) were associated with the development of emphysematous changes, neutrophil accumulation in the alveolar space, and impaired diffusing capacity. ABSTRACT: Background and objective: Combined pulmonary fibrosis and emphysema (CPFE) is characterized by upper lobe emphysema together with lower lobe fibrosis. The aim of this study was to examine whether cytokine levels in the alveolar space are associated with emphysematous changes superimposed on pulmonary fibrosis. Methods: Consecutive patients (n= 102), diagnosed with pulmonary fibrosis were retrospectively evaluated. Cytokine levels and differential cell counts in bronchoalveolar lavage (BAL)fluid, pulmonary function, computed tomography (CT) scores, and levels of serum markers, were compared between patients with or without emphysema. Results: Among the 102 patients (14 females, mean age 68 years), 38 (37%) had evidence of upper lobe emphysema on CT. Levels of epithelial neutrophil activating peptide 78 (ENA-78/CXCL5) and interleukin (IL)-8/CXCL8 in BAL fluid, were significantly higher in patients with emphysema. Vital capacity (VC, % predicted) was greater and ratio of forced expiratory volume in 1 s/forced vital capacity and diffusing capacity of carbon monoxide (DL(CO) )/alveolar volume (V(A) ) were lower in patients with emphysema. CXCL8 and CXCL5 levels were associated with percentage or absolute numbers of neutrophils in BAL fluid. In addition, CXCL8 levels were inversely correlated with VC and DL(CO) /V(A) , and positively correlated with CPI and the extent of areas of low attenuation on CT. Conclusions: Increased CXC chemokine levels in the airspaces may be associated with emphysematous lung changes in patients with pulmonary fibrosis. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
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Authors:
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Sadatomo Tasaka; Kosuke Mizoguchi; Yohei Funatsu; Ho Namkoong; Wakako Yamasawa; Makoto Ishii; Naoki Hasegawa; Tomoko Betsuyaku |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-20 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Affiliation:
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Division of Pulmonary Medicine, Department of Medicine, Department of Laboratory Medicine, Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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