Document Detail

Cytokine profile associated with chronic and acute human schistosomiasis mansoni.
MedLine Citation:
PMID:  18949326     Owner:  NLM     Status:  MEDLINE    
The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma (IFN-gamma) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-gamma when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific.
Clarice Neuenschwander Lins de Morais; Joelma Rodrigues de Souza; Wlademir Gomes Melo; Marcílio L Aroucha; Paulo Miranda; Ana Lúcia Coutinho Domingues; Frederico Guilherme Coutinho Abath; Silvia Maria Lucena Montenegro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Memórias do Instituto Oswaldo Cruz     Volume:  103     ISSN:  1678-8060     ISO Abbreviation:  Mem. Inst. Oswaldo Cruz     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-24     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502619     Medline TA:  Mem Inst Oswaldo Cruz     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães-Fiocruz, Recife, PE, Brasil.
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MeSH Terms
Acute Disease
Case-Control Studies
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Interferon-gamma / biosynthesis*
Interleukin-3 / biosynthesis*
Interleukin-4 / biosynthesis*
Middle Aged
Schistosomiasis mansoni / immunology*,  metabolism
Young Adult
Reg. No./Substance:
0/Interleukin-3; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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