| Cytokine production of stimulated whole blood cultures in rheumatoid arthritis patients receiving short-term infliximab therapy. | |
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MedLine Citation:
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PMID: 15804598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with rheumatoid arthritis (RA) treated with anti-tumor necrosis factor (TNF) strategies have an increased susceptibility to infections, especially those caused by intracellular pathogens. In this study we assessed the cytokine production capacity in patients with RA and we further investigated whether anti-TNF therapy modulates the production of pro-inflammatory cytokines involved in the resistance against infections. Whole blood cultures from 10 RA patients and 10 healthy controls were stimulated with heat-killed Candida albicans, Salmonella typhimurium, Staphyloccocus aureus, Aspergillus fumigatus or Mycobacterium tuberculosis and production of interleukin (IL)-1beta, IL-6, IL-10, interferon (IFN)-gamma and TNF-alpha was measured. Before anti-TNF therapy, whole blood cultures from RA patients released significantly less IFN-gamma than healthy controls after stimulation with all tested microorganisms. Short-term anti-TNF therapy did not have an inhibitory effect on the release of the cytokines tested. We conclude that cells of patients with RA have a strongly reduced production capacity of IFN-gamma after bacterial challenge. Although short-term therapy with anti-TNF agents did not further decrease the release of other proinflammatory cytokines, the combination of defective IFN-gamma production in basal conditions and TNF neutralization during anti-TNF therapy is likely to be responsible for the higher susceptibility to infections in patients with RA. |
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Authors:
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Calin Popa; Mihai G Netea; Pilar Barrera; Timothy R D S Radstake; Piet L van Riel; Bart-Jan Kullberg; Jos W M Van der Meer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cytokine Volume: 30 ISSN: 1043-4666 ISO Abbreviation: Cytokine Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-04 Completed Date: 2005-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 72-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Medical Center St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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pharmacology*,
therapeutic use Antirheumatic Agents / pharmacology*, therapeutic use Arthritis, Rheumatoid / blood*, drug therapy, immunology Aspergillus fumigatus / pathogenicity Blood Cells / drug effects, immunology, metabolism*, microbiology Candida albicans / pathogenicity Case-Control Studies Cytokines / blood* Humans Inflammation Mediators / blood Mycobacterium tuberculosis / pathogenicity Reference Values Salmonella typhimurium / pathogenicity Tumor Necrosis Factor-alpha / drug effects, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Cytokines; 0/Inflammation Mediators; 0/Tumor Necrosis Factor-alpha; 0/infliximab |
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