Document Detail

Cytokine production in unmedicated and treated schizophrenic patients.
MedLine Citation:
PMID:  11059907     Owner:  NLM     Status:  MEDLINE    
Recent findings have strengthened the hypothesis that immunological dysfunctions may contribute towards the multifactorial pathogenesis of schizophrenia. The validity of these findings is questioned by the fact that most studied subjects have received potentially immunomodulatory medication upon investigation. In order to rule out such confounding effects, 24 initially unmedicated acutely ill schizophrenic patients were studied immunologically and psychiatrically (PANSS) before and during 4 weeks of neuroleptic treatment. The production of IFN-gamma was decreased upon admission and after 2 weeks of treatment compared to matched healthy controls. No differences in IL-2 and IFN-gamma production between unmedicated and medicated states were observed. These results do not support the notion that neuroleptic medication in vivo might influence TH1 cytokine production in schizophrenia.
M Rothermundt; V Arolt; J Leadbeater; M Peters; S Rudolf; H Kirchner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  11     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-29     Completed Date:  2001-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3385-8     Citation Subset:  IM    
Department of Psychiatry, University of Münster, Germany.
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Cytokines / biosynthesis*
Interferon-gamma / biosynthesis
Interleukin-2 / biosynthesis
Reference Values
Schizophrenia / drug therapy*,  metabolism*
Schizophrenic Psychology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Cytokines; 0/Interleukin-2; 82115-62-6/Interferon-gamma

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