Document Detail


Cytokine levels in patients with a very low left ventricular ejection fraction after open heart surgery.
MedLine Citation:
PMID:  11889965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Cardiopulmonary bypass and cardiac operations are obligatorily connected with systemic inflammatory reaction. Production of proinflammatory cytokines is responsible also for negative effects on the myocardial function. OBJECTIVE OF STUDY: Follow-up of the dynamic changes of proinflammatory and antiinflammatory cytokine levels in patients with left ventricular dysfunction during the first week after cardiac surgery. PATIENTS AND METHODS: A total of nine patients with a very low left ventricular ejection fraction (22.75 +/- 0.65%) who had undergone cardiac surgery (for coronary artery bypass grafting or aortic valve reconstruction) were investigated during the first after week operation. The preoperative and postoperative plasma levels of tumor necrosis factor (TNF), interleukin-8 (IL-8) and interleukin-10 (IL-10) were estimated by means of ELISA technique. RESULTS: With respect to the preoperative levels, on the first postoperative day the levels IL-8 (from 9.36 to 16.65 pg/ml) (p < 0.05) and of IL-10 (from 6.93 to 28.09 pg/ml) (p < 0.02) significantly rose with a stepwise decrease down to the seventh day after surgery. From the third to seventh day an insignificant increase in TNF level was also noted. CONCLUSIONS: The results have shown that open heart surgery in patients with a severe left ventricular dysfunction evoked a systemic inflammatory response demonstrated by early increase in proinflammatory cytokine IL-8 and was accompanied by increased level of antiinflammatory cytokine IL-10. Despite stepwise decrease in IL-8 levels, they did not reach the preoperative levels, not even on the seventh postoperative day. (Tab. 1, Fig. 3, Ref. 21.)
Authors:
L Martakova; I Olejarova; K Danova; V Fischer; V Parrak; M Bucova; I Pechan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  102     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-03-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  548-51     Citation Subset:  IM    
Affiliation:
St. Cyril and Methods Hospital, Bratislava-Petrzalka, Slovakia.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiac Surgical Procedures / adverse effects*
Cytokines / blood*
Female
Humans
Interleukin-10 / blood
Interleukin-8 / blood
Male
Middle Aged
Stroke Volume*
Tumor Necrosis Factor-alpha / analysis
Ventricular Dysfunction, Left / blood*,  etiology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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