Document Detail


Cytokine inhibitors in patients with heart failure and impaired functional capacity.
MedLine Citation:
PMID:  9293404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines are proteins with pleiotropic biological effects, but the pathophysiologic role of cytokine inhibitors in advanced cardiac disease remains unclear. We assessed the levels of tumor necrosis factor (TNF)-alpha and its soluble receptors I (sTNF-RI) and II (sTNF-RII), soluble interleukin-1 receptor antagonist (sIL-1 Ra), and interleukin-6 soluble receptor (IL-6 sR) in sera from 11 patients with severe chronic congestive heart failure (mean left ventricular ejection fraction 19 +/- 6%; mean symptom-limited oxygen consumption 13 +/- 4 ml/min per kg) and 11 healthy volunteers. The serum concentrations of TNF, sTNF-RI, and sIL-1 Ra, but not of sTNF-RII and IL-6 sR, were significantly increased in heart failure patients. Importantly, their symptom-limited oxygen consumption was strongly associated with both sTNF-RI (R = -0.68, p = 0.04) and sIL-1 Ra (R = -0.77, p = 0.01). These results suggest that cytokine inhibitors from different receptor families may be involved in functional disability, a characteristic feature in patients with severe congestive heart failure. Understanding the response of cytokine inhibitors to heart failure might have therapeutic value as interventions against cytokines become available.
Authors:
E Missov; A Campbell; B Lebel
Related Documents :
1989124 - Risk for postoperative congestive heart failure.
11283124 - Congestive heart failure after treatment for wilms' tumor: a report from the national w...
21286844 - Intracoronary delivery of mesenchymal stem cells reduces proarrhythmogenic risks in swi...
3370184 - Cardiomyopathy in the kearns-sayre syndrome.
21307004 - Elevated cardiac biomarkers with normal right ventricular size indicate an unlikely dia...
22882924 - Combined effect of atorvastatin and probucol on plasma cystatin c levels and severity o...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  61     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  749-54     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / blood
Case-Control Studies
Cytokines / antagonists & inhibitors*
Heart Failure / blood,  physiopathology*
Hemodynamics / physiology*
Humans
Interleukin 1 Receptor Antagonist Protein
Interleukin-6 / blood
Linear Models
Middle Aged
Receptors, Interleukin / blood
Receptors, Interleukin-1 / antagonists & inhibitors
Receptors, Interleukin-6
Receptors, Tumor Necrosis Factor / blood
Sialoglycoproteins / blood
Solubility
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Cytokines; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Interleukin-1; 0/Receptors, Interleukin-6; 0/Receptors, Tumor Necrosis Factor; 0/Sialoglycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased plasma soluble intercellular adhesion molecule-1 levels in patients with acute myocardial ...
Next Document:  Effects of various doses of intracoronary verapamil on coronary resistance vessels in humans.