Document Detail

Cytokine inhibitors in patients with heart failure and impaired functional capacity.
MedLine Citation:
PMID:  9293404     Owner:  NLM     Status:  MEDLINE    
Cytokines are proteins with pleiotropic biological effects, but the pathophysiologic role of cytokine inhibitors in advanced cardiac disease remains unclear. We assessed the levels of tumor necrosis factor (TNF)-alpha and its soluble receptors I (sTNF-RI) and II (sTNF-RII), soluble interleukin-1 receptor antagonist (sIL-1 Ra), and interleukin-6 soluble receptor (IL-6 sR) in sera from 11 patients with severe chronic congestive heart failure (mean left ventricular ejection fraction 19 +/- 6%; mean symptom-limited oxygen consumption 13 +/- 4 ml/min per kg) and 11 healthy volunteers. The serum concentrations of TNF, sTNF-RI, and sIL-1 Ra, but not of sTNF-RII and IL-6 sR, were significantly increased in heart failure patients. Importantly, their symptom-limited oxygen consumption was strongly associated with both sTNF-RI (R = -0.68, p = 0.04) and sIL-1 Ra (R = -0.77, p = 0.01). These results suggest that cytokine inhibitors from different receptor families may be involved in functional disability, a characteristic feature in patients with severe congestive heart failure. Understanding the response of cytokine inhibitors to heart failure might have therapeutic value as interventions against cytokines become available.
E Missov; A Campbell; B Lebel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  61     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  749-54     Citation Subset:  IM    
Department of Cardiology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France.
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MeSH Terms
Antigens, CD / blood
Case-Control Studies
Cytokines / antagonists & inhibitors*
Heart Failure / blood,  physiopathology*
Hemodynamics / physiology*
Interleukin 1 Receptor Antagonist Protein
Interleukin-6 / blood
Linear Models
Middle Aged
Receptors, Interleukin / blood
Receptors, Interleukin-1 / antagonists & inhibitors
Receptors, Interleukin-6
Receptors, Tumor Necrosis Factor / blood
Sialoglycoproteins / blood
Reg. No./Substance:
0/Antigens, CD; 0/Cytokines; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Interleukin-1; 0/Receptors, Interleukin-6; 0/Receptors, Tumor Necrosis Factor; 0/Sialoglycoproteins

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