Document Detail

Cytokine-inducing activity of family 2 cystatins.
MedLine Citation:
PMID:  11154074     Owner:  NLM     Status:  MEDLINE    
Cystatins are physiological cysteine proteinase inhibitors. Here we report a novel function for some family 2 cystatins that is not related to these activities. The release of interleukin-6 (IL-6) and interleukin-8 (IL-8) by the gingival fibroblasts and that of IL-6 by murine splenocytes were measured using ELISA systems specific for these cytokine molecules. Family 2 cystatins, including cystatins C, SA1, SA2, S, and egg white cystatin, upregulated the IL-6 production by two-lasts at physiological concentrations. After complete saturation with papain, those family 2 cystatins still upregulated IL-6 production, suggesting that the papain-inhibitory site was not involved in the cytokine-inducing activity.
T Kato; T Imatani; T Miura; K Minaguchi; E Saitoh; K Okuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological chemistry     Volume:  381     ISSN:  1431-6730     ISO Abbreviation:  Biol. Chem.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9700112     Medline TA:  Biol Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1143-7     Citation Subset:  IM    
Department of Microbiology, Tokyo Dental College, Chiba, Japan.
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MeSH Terms
Cystatins / metabolism*,  pharmacology
Cysteine Proteinase Inhibitors / metabolism*,  pharmacology
Fibroblasts / drug effects,  metabolism
Gingiva / cytology
Interleukin-1 / metabolism*
Interleukin-6 / genetics,  metabolism*
Interleukin-8 / metabolism*
Mice, Inbred BALB C
Spleen / cytology
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Cystatins; 0/Cysteine Proteinase Inhibitors; 0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha

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