Document Detail


Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group.
MedLine Citation:
PMID:  11315919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the involvement of candidate cytokine genes in the pathogenesis of juvenile idiopathic arthritis (JIA). METHODS: Single nucleotide polymorphisms and intragenic microsatellite markers within 8 candidate cytokine genes (interleukin-1alpha [IL-1alpha], IL-2, IL-4, IL-6, IL-10, interferon-alpha1 [IFNA1], interferon-gamma [IFNG], and interferon regulatory factor 1 [IRF-1]) were investigated in 417 Caucasian patients with clinically characterized JIA and a panel of 276 unrelated, healthy Caucasian controls, all from the United Kingdom. RESULTS: A novel 3'-untranslated region (3'UTR) polymorphism in IRF-1 was found to be associated with susceptibility to JIA (corrected P = 0.002). No significant association with IL-1alpha, IL-2, IL-4, IL-6, IL-10, IFNA1, or IFNG was observed. CONCLUSION: An association between JIA and a previously unreported 3'UTR polymorphism of IRF-1 was observed. This association was not found to be specific to any particular JIA subgroup. This suggests that IRF-1 may contribute to a common pathogenesis shared by all JIA patients, regardless of clinical phenotype. This is most likely to be a genetic contribution to the chronic inflammatory process that underlies JIA pathology.
Authors:
R P Donn; J H Barrett; A Farhan; A Stopford; L Pepper; E Shelley; N Davies; W E Ollier; W Thomson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  44     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-23     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  802-10     Citation Subset:  AIM; IM    
Affiliation:
Arthritis Research Campaign Epidemiology Unit, Manchester, UK.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions
Arthritis, Juvenile Rheumatoid / etiology,  genetics*
Child
Child, Preschool
Cytokines / genetics*
DNA Primers / chemistry
DNA-Binding Proteins / genetics
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Interferon Regulatory Factor-1
Microsatellite Repeats
Phosphoproteins / genetics
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Cytokines; 0/DNA Primers; 0/DNA-Binding Proteins; 0/IRF1 protein, human; 0/Interferon Regulatory Factor-1; 0/Phosphoproteins

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