Document Detail


Cytokine gene polymorphisms and sudden infant death syndrome.
MedLine Citation:
PMID:  19958302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Several studies indicate that the mucosal immune system is stimulated in cases of sudden infant death syndrome (SIDS), and our hypothesis is that this immune reaction is because of an unfavourable combination of functional polymorphisms in the cytokine genes. METHODS: Thus, in this study, single nucleotide polymorphisms (SNPs) in the genes encoding IL-6, IL-8, IL-12, IL-13, IL-16, IL-18 and IFNgamma were investigated in 148 SIDS cases, 56 borderline SIDS cases, 41 cases of infectious death and 131 controls. RESULTS: Regarding genotype distribution, no differences between the investigated groups were found. However, in the SIDS group, the genotypes IL-8 -251AA/AT and IL-8 -781CT/TT were significantly more frequent in the SIDS cases found dead in a prone sleeping position, compared with SIDS cases found dead in other sleeping positions. In addition, there was an association between fever prior to death and the genotype IL-13 +4464GG in the cases of infectious death. CONCLUSION: This study indicates that specific interleukin genotypes are a part of a genetic make up that make infants sleeping prone at risk for SIDS.
Authors:
L Ferrante; S H Opdal; A Vege; To Rognum
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-01
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  384-8     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Oslo, Oslo, Norway. linda.ferrante@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Genetic Predisposition to Disease*
Genotype
Humans
Infant
Interferon-gamma / genetics*
Interleukins / genetics*
Male
Polymorphism, Single Nucleotide*
Prone Position
Risk Factors
Sleep
Sudden Infant Death / genetics*
Chemical
Reg. No./Substance:
0/Interleukins; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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