| Cytokine gene polymorphisms in sarcoidosis. | |
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MedLine Citation:
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PMID: 21086908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sarcoidosis is a disease characterized by granuloma formation in many organs, but mostly in lung and lymph nodes. The immunopathogenic background of the disease is probably based on disregulation of immune response to different antigens. The imbalance of immune reactivity might be influenced by genetic background. In our study, we have investigated cytokine genetic polymorphisms in sarcoidosis group and compared the results with that of a group of healthy volunteers. METHODS: Thirty one sarcoidosis patients were enrolled to our study. Basic demographic data were collected. Polymorphisms in the promoter regions of the IL-1alpha, IL-1beta, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, TNF-alpha, IFN-gamma and in the translated regions of the TGF-beta, IL-1 beta, IL-2, IL-4 and IL-4RA genes were characterized. RESULTS: For IL-10, the (-819) and (-592) CC homozygosity was statistically more frequent in the sarcoidosis group compared to healthy controls. According to the haplotypes, the majority of sarcoidosis patients had IL-10 (-1082)(-819)(-592) ACC haplotype 2 compared to controls with ATA in most of the cases. CONCLUSIONS: The results of our study support the hypothesis of a genetically encoded immune regulation imbalance in sarcoidosis. The high-producer IL-10 (-819) and (-592) CC genotypes and intermediate- producer IL-10 (-1082) (-819) (-592) ACC haplotype 2 present in the majority of our sarcoidosis patients could support the role of genetically encoded disregulation of cell- mediated immune response to an unknown antigen. |
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Authors:
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M Vasakova; M Sterclova; L Kolesar; A Slavcev; J Skibova; I Striz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders Volume: 27 ISSN: 1124-0490 ISO Abbreviation: Sarcoidosis Vasc Diffuse Lung Dis Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-11-19 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610928 Medline TA: Sarcoidosis Vasc Diffuse Lung Dis Country: Italy |
Other Details:
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Languages: eng Pagination: 70-5 Citation Subset: IM |
Affiliation:
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Department of Respiratory Diseases, 1st Medical School Charles University and University Thomayer Hospital Prague, Czech Republic. martina.vasakova@ftn.cz |
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Chi-Square Distribution Cytokines / genetics* Czech Republic European Continental Ancestry Group / genetics Female Gene Frequency Genetic Predisposition to Disease Haplotypes Homozygote Humans Interleukin-10 / genetics Male Middle Aged Phenotype Polymorphism, Genetic* Promoter Regions, Genetic Sarcoidosis / ethnology, genetics*, immunology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/IL10 protein, human; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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