| Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages. | |
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MedLine Citation:
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PMID: 23062580 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To determine association of cytokine gene polymorphism with risk for recurrent miscarriages (RM). DESIGN: Retrospective case-control study on northern Indian RM cases versus control subjects. SETTING: Medical facility. PATIENT(S): A total of 200 women with at least three unexplained spontaneous abortions before 20 weeks of gestation. INTERVENTION(S): Subjects were genotyped by polymerase chain reaction amplification followed by restriction digestion and allele-specific oligonucleotides. MAIN OUTCOME MEASURE(S): Detection of pro- and antiinflammatory gene polymorphism genotypes and allele frequencies. RESULT(S): We applied dominant and recessive models of inheritance, showing no association among T(H)2 [interleukin (IL) 10 (592 C/A) and transforming growth factor β] gene polymorphisms, while significant association was observed between T(H)2 [IL-4 (C590T), IL-6 (G174C), IL-10 (1082A/G and 819C/T)], and T(H)1 [interferon-γ (+874A/T)] with RM compared with control subjects. However, when classification and regression tree analysis was applied, this effect disappeared and demonstrated that IL-10 plays an important role in maintenance of pregnancy. CONCLUSION(S): Interleukin-10 acts as an immunosuppressive by keeping a balance of pro- and antiinflammatory signals that coordinate the satisfactory development of pregnancy, placental growth, and remodeling for favorable pregnancy outcome. |
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Authors:
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Farah Parveen; Anju Shukla; Suraksha Agarwal |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
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Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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