Document Detail

Cytokine expression of macrophages in HIV-1-associated vacuolar myelopathy.
MedLine Citation:
PMID:  8492917     Owner:  NLM     Status:  MEDLINE    
Macrophages are frequently present within the periaxonal and intramyelinic vacuoles that are located primarily in the posterior and lateral funiculi of the thoracic spinal cord in HIV-associated vacuolar myelopathy. But the role of these macrophages in the formation of the vacuoles is unclear. One hypothesis is that cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha, are produced locally by macrophages and have toxic effects on myelin or oligodendrocytes. The resulting myelin damage eventually culminates in the removal of myelin by macrophages and vacuole formation. We studied thoracic spinal cord specimens taken at autopsy from HIV-positive (+) and HIV-negative individuals. The predominant mononuclear cells present in HIV+ spinal cords are macrophages. They are located primarily in the posterior and lateral funiculi regardless of the presence or absence of vacuolar myelopathy. Macrophages and microglia are more frequent in HIV+ than HIV-negative individuals and these cells frequently stain for class I and class II antigens, IL-1, and TNF-alpha. Activated macrophages positive for IL-1 and TNF-alpha are great increased in the posterior and lateral funiculi of HIV+ individuals with and without vacuolar myelopathy, suggesting they are present prior to the development of vacuoles. Cytokines, such as TNF-alpha, may be toxic for myelin or oligodendrocytes, leading to myelin damage and removal by macrophages and vacuole formation.
W R Tyor; J D Glass; N Baumrind; J C McArthur; J W Griffin; P S Becker; D E Griffin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1002-9     Citation Subset:  AIM; IM; X    
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
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MeSH Terms
Acquired Immunodeficiency Syndrome / pathology,  physiopathology*
Cytokines / analysis,  metabolism*
HIV Seropositivity / pathology*,  physiopathology
HLA-D Antigens / analysis
Interleukin-1 / analysis,  blood,  cerebrospinal fluid
Macrophages / metabolism*,  pathology
Middle Aged
Spinal Cord / pathology*
Spinal Cord Diseases / etiology*,  pathology
Tumor Necrosis Factor-alpha / analysis,  cerebrospinal fluid
Vacuoles / ultrastructure*
Grant Support
5NP01-NS-26643/NS/NINDS NIH HHS; NS-07179/NS/NINDS NIH HHS; R01-A1-72634//PHS HHS
Reg. No./Substance:
0/Cytokines; 0/HLA-D Antigens; 0/Interleukin-1; 0/Tumor Necrosis Factor-alpha
Comment In:
Neurology. 1994 Mar;44(3 Pt 1):578-9   [PMID:  8145942 ]

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