| Cytokine expression in the duodenal mucosa of patients with visceral leishmaniasis. | |
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MedLine Citation:
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PMID: 20802937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Visceral leishmaniasis (VL) is a neglected tropical disease with a complex immune response in different organs. This pattern of organ-specific immune response has never been evaluated in the gastrointestinal tract. The aim of this study was to determine the in situ immune response in duodenal biopsies on patients with VL. METHODS: A case-control study was conducted on 13 patients with VL in comparison with nine controls. The immune response was evaluated using immunohistochemistry, for CD4, CD8, CD68, IL-4, IFN-gamma, TNF-alpha and IL-10. Histological findings from the villi, crypts and inflammatory process were analyzed. RESULTS: All the cases of VL presented Leishmania antigens. No antigen was detected in the control group. The villus size was greater in the VL patients (p < 0.05). CD68 (macrophages) and CD4 levels were higher in the VL patients (p < 0.05). No differences in the expression of CD8, TNF-alpha, IL-10 or IL-4 were demonstrated. The number of cells expressing IFN-gamma was lower in the VL patients (p < 0.05). CONCLUSIONS: Low levels of cytokines were found in the gastrointestinal tract of patients with VL. This pattern was not found in other organs affected by the disease. Immunotolerance of this tissue against Leishmania could explain these findings, as occurs with intestinal bacteria. |
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Authors:
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Kleber Giovanni Luz; Felipe Francisco Tuon; Maria Irma Seixas Duarte; Guilherme Mariz Maia; Paulo Matos; Ana Maria de Oliveira Ramos; Antônio Carlos Nicodemo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista da Sociedade Brasileira de Medicina Tropical Volume: 43 ISSN: 1678-9849 ISO Abbreviation: Rev. Soc. Bras. Med. Trop. Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2011-04-04 Revised Date: 2011-06-24 |
Medline Journal Info:
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Nlm Unique ID: 7507456 Medline TA: Rev Soc Bras Med Trop Country: Brazil |
Other Details:
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Languages: eng Pagination: 393-5 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, Federal University of Rio Grande do Norte, Natal, RN, Brazil. luz@ufrnet.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Child Child, Preschool Cytokines / analysis*, immunology Duodenum / immunology*, parasitology Humans Immunohistochemistry Infant Intestinal Mucosa / immunology*, parasitology Leishmaniasis, Visceral / immunology*, pathology Macrophages / immunology* T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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