Document Detail


Cytokine blocking agents in dermatology.
MedLine Citation:
PMID:  12464154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines are intercellular messengers that have an important role in the development and maintenance of cutaneous inflammation. The primacy of cytokines in eliciting cutaneous immune responses makes them a highly attractive target for new biological response modifiers. Targeting of cytokines is still in its infancy for therapy of skin disease. However, blocking tumour necrosis factor alpha by infliximab or etanercept has shown particular promise, especially in the management of psoriasis. Anecdotally, this approach is also effective for a variety of dermatological conditions including pyoderma gangrenosum and Behçet's syndrome. We review the current and prospective roles of cytokine blocking agents in the treatment of skin disease.
Authors:
J D L Williams; C E M Griffiths
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  27     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-03-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  IM    
Affiliation:
The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK. jasondwilliams@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Antibodies, Monoclonal / therapeutic use*
Cytokines / antagonists & inhibitors*
Dermatologic Agents / therapeutic use*
Humans
Immunoglobulin G / therapeutic use*
Receptors, Tumor Necrosis Factor / therapeutic use*
Skin Diseases / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Cytokines; 0/Dermatologic Agents; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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