| Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. | |
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MedLine Citation:
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PMID: 20187772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of carbohydrate ingestion after maximal lengthening contractions of the knee extensors on circulating concentrations of myocellular proteins and cytokines, and cytokine mRNA expression in muscle. Using a cross-over design, 10 healthy males completed 5 sets of 10 lengthening (eccentric) contractions (unilateral leg press) at 120% 1 repetition-maximum. Subjects were randomized to consume a carbohydrate drink (15% weight per volume; 3 g/kg BM) for 3 h after exercise using one leg, or a placebo drink after exercise using the contralateral leg on another day. Blood samples (10 mL) were collected before exercise and after 0, 30, 60, 90, 120, 150, and 180 min of recovery. Muscle biopsies (vastus lateralis) were collected before exercise and after 3 h of recovery. Following carbohydrate ingestion, serum concentrations of glucose (30-90 min and at 150 min) and insulin (30-180 min) increased (P < 0.05) above pre-exercise values. Serum myoglobin concentration increased ( approximately 250%; P < 0.05) after both trials. In contrast, serum cytokine concentrations were unchanged throughout recovery in both trials. Muscle mRNA expression for IL-8 (6.4-fold), MCP-1 (4.7-fold), and IL-6 (7.3-fold) increased substantially after carbohydrate ingestion. TNF-alpha mRNA expression did not change after either trial. Carbohydrate ingestion during early recovery from exercise-induced muscle injury may promote proinflammatory reactions within skeletal muscle. |
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Authors:
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Megan L R Ross; Shona L Halson; Katsuhiko Suzuki; Andrew Garnham; John A Hawley; David Cameron-Smith; Jonathan M Peake |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: 30 ISSN: 1557-7465 ISO Abbreviation: J. Interferon Cytokine Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-09-22 Revised Date: 2010-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: United States |
Other Details:
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Languages: eng Pagination: 329-37 Citation Subset: IM |
Affiliation:
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Exercise Metabolism Group, School of Medical Sciences, RMIT University , Bundoora, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / biosynthesis, genetics Convalescence* Cytokines / genetics, metabolism* Dietary Carbohydrates / administration & dosage* Eating Exercise / physiology Humans Insulin / biosynthesis, blood, genetics Male Muscle, Skeletal / drug effects*, injuries, physiology Muscular Diseases / blood, diet therapy*, physiopathology Myoglobin / biosynthesis, blood, genetics Recovery of Function / drug effects Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cytokines; 0/Dietary Carbohydrates; 0/Myoglobin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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