Document Detail


Cytokine patterns differ seasonally between women with and without uterine leiomyomata.
MedLine Citation:
PMID:  23614810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Uterine leiomyomata are the most common reproductive tumor in women, and their cause is not known.
METHODS OF STUDY: Plasma samples from 155 women (74 with and 81 without ultrasound-confirmed leiomyoma) from a new study of leiomyoma risk factors in the Detroit, Michigan area, were examined for any cross-sectional associations between commonly examined cytokines and leiomyoma presence.
RESULTS: Associations varied by season of sample collection defined a priori as winter (December-February) and non-winter seasons. In the winter months, interleukin (IL)13 and IL17 were positively and IP10 was inversely associated with having a leiomyoma. In the non-winter samples, VEGF, G-CSF, and IP10 were positively associated and Monocyte chemotactic protein-1, IL13, and IL17 were inversely associated with having a leiomyoma. Associations were not changed by adjustment for age or BMI.
CONCLUSIONS: These data suggest that new insight into leiomyoma formation may be acquired through investigation of the immune system.
Authors:
Ganesa Wegienka; Donna Day Baird; Tracy Cooper; Kimberley J Woodcroft; Suzanne Havstad
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2013-04-25
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  70     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-13     Completed Date:  2014-03-31     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  327-35     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Age Factors
Body Mass Index
Cross-Sectional Studies
Cytokines / blood
Female
Follow-Up Studies
Humans
Leiomyoma / diagnosis*,  immunology*,  pathology
Michigan
Seasons
Uterine Neoplasms / diagnosis*,  immunology*,  pathology
Uterus / pathology,  ultrasonography*
Young Adult
Grant Support
ID/Acronym/Agency:
Z01 ES049013-13/ES/NIEHS NIH HHS; Z01 ES049013-14/ES/NIEHS NIH HHS; ZIA ES049013-15/ES/NIEHS NIH HHS; ZIA ES049013-16/ES/NIEHS NIH HHS; ZIA ES049013-17/ES/NIEHS NIH HHS; ZIA ES049013-18/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections
Comment In:
Am J Reprod Immunol. 2013 Oct;70(4):264   [PMID:  23841596 ]
Am J Reprod Immunol. 2013 Oct;70(4):263   [PMID:  23845097 ]

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