| Cytokine and Chemokine Responses to Selected Early Secreted Antigenic Target-6 and Culture Filtrate Protein-10 Peptides in Tuberculosis. | |
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MedLine Citation:
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PMID: 21133811 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cytokine [tumor necrosis factor-α, interleukin-2 (IL-2), IL-4] and chemokine [regulated upon activation normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein-1] responses to selected early secreted antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) peptides were studied in healthy household contacts and patients with pulmonary tuberculosis (PTB). It was observed that Th1 cytokines and chemokine RANTES positive T cells were elevated in response to the peptides Esp1, Esp6, Cfp6, and Cfp8 in healthy household contacts. IL-4 positive T cells were enhanced by Esp1 and Esp6 in PTB. Monocyte chemoattractant protein-1 positive monocytes increased in response to the peptides Esp1, Esp6, Cfp8, and Cfp9 in PTB. These peptides deserve attention for further immune studies. |
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Authors:
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Madhan Kumar Murthy; Tamilmani Kaliappan; Alamelu Raja |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-6 |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: - ISSN: 1557-7465 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Immunology, Tuberculosis Research Centre (ICMR) , Chetput, Chennai, India . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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