| Cytokeratin-positive hepatocytes in the hilar region: An immunohistochemical study using livers from fetuses and elderly individuals. | |
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MedLine Citation:
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PMID: 21458250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Cytokeratin-positive primitive hepatocytes or hepatic progenitor cells have been described in the fetal ductal plate, as well as in the adult canals of Hering. We examined the fate of ductal plate cells in the hilar region of the liver. METHODS: Using liver sections from 10 fetuses and 15 elderly cadavers, we performed immunohistochemistry for cytokeratins 14 and 19, smooth muscle actin, vimentin and CD34. RESULTS: At 18 weeks of gestation, cytokeratin-positive cells were evident in the ductal plate and liver parenchyma, which were separated by a narrow space. At 25 weeks, most of these positive cells had disappeared, but the remnant cells were aligned along the parenchymal margins facing the hilar portal pedicle in addition to the canals of Hering in the peripheral portal pedicle. The gallbladder bed did not contain cytokeratin 19-positive cells. Notably, even livers in the elderly contained such marginal positive cells in the hilar region. These cells were negative for smooth muscle actin and CD34, but tended to be positive for vimentin. CONCLUSIONS: Cytokeratin-positive hepatic progenitor cells are likely to exist along the hilar portal pedicle even in adults. These hilar marginal hepatocytes seem to be derived not from the fetal ductal plate, but from the liver parenchyma. |
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Authors:
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Woo Sung Moon; Baik Hwan Cho; Shogo Hayashi; Ji Hyun Kim; Gen Murakami; Yoshitaka Fukuzawa; Takashi Nakano |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-30 |
Journal Detail:
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Title: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Volume: - ISSN: 1618-0402 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963897 Medline TA: Ann Anat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Pathology, Chonbuk National University College of Medicine, Jeonju, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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