Document Detail

Cytokeratin patterns in the epidermis of human ovarian mature cystic teratomas.
MedLine Citation:
PMID:  2464541     Owner:  NLM     Status:  MEDLINE    
Using a battery of monoclonal antibodies, we investigated the cytokeratin pattern in the epidermides of 12 human ovarian mature cystic teratomas (MCTs) and compared them with those of infant, adult, and fetal skin. Histologically, two types of epidermal layers were identified in the MCTs, a mature layer and an immature layer. The mature layer was similar to the epidermis of infants and adults, while the immature layer resembled stratified nonkeratinizing and metaplastic squamous epithelium. The cytokeratin pattern of the histologically mature epidermis in MCT was either similar to that in infants and adults or was of the fetal type. The cytokeratin expression of the histologically immature epidermis in MCT also showed many similarities to the fetal cytokeratin pattern. We conclude that histologic maturity of the epidermis in MCT is not necessarily expressed by the cytokeratin pattern, which reflects the state of molecular rather than histologic differentiation. Since prognosis in germ cell tumors is usually related to the degree of tissue maturation, our observations raise the possibility that the cytokeratin profile may eventually prove to be a valuable prognostic tool in some of the neoplasms that contain epithelial elements.
B Czernobilsky; B Lifschitz-Mercer; A Luzon; N Jacob; H Ben-Hur; S Gorbacz; M Fogel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human pathology     Volume:  20     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Department of Pathology, Kaplan Hospital, Rehovot, Israel.
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MeSH Terms
Dermoid Cyst / metabolism*,  pathology
Epidermis / metabolism*,  pathology
Fetus / anatomy & histology,  metabolism
Gestational Age
Keratins / metabolism*
Ovarian Neoplasms / metabolism*,  pathology
Reg. No./Substance:

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