| Cytokeratin expression in initial oral mucositis of head and neck irradiated patients. | |
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MedLine Citation:
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PMID: 16448923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this work was to study cytokeratin (Ck) expression in initial radiation-induced oral mucositis. STUDY DESIGN: Eleven cases of initial radiomucositis of the buccal mucosa and 9 normal specimens were immunostained for Ck 1, 5, 6, 7, 8, 10, 14, 16, 18, and 19 by immunoperoxidase method. RESULTS: Expression of Ck 1, 6, 10, and 16 was stronger in mucositis than in normal mucosa. Ck 7, 8, and 18 were negative for both control and study groups. Ck 5, 13, and 14 were positive for both groups, nevertheless suprabasal staining for Ck 14 was more evident in mucositis than in the control group. Sporadic staining for Ck 19 was observed in 1 case of mucositis and in 2 controls. CONCLUSIONS: Increased Ck expression can be associated with the reactive proliferation of the epithelium and increasing resistance of the oral mucosa during the initial phases of radiotherapy. |
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Authors:
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Paulo Rogério Ferreti Bonan; Estela Kaminagakura; Fábio Ramoa Pires; Pablo Agustin Vargas; Oslei Paes de Almeida |
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Publication Detail:
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Type: Journal Article Date: 2005-09-19 |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 101 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-01 Completed Date: 2006-03-14 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 205-11 Citation Subset: D; IM |
Affiliation:
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School of Dentistry, State University of Montes Claros, Minas Gerais, Brazil. pbonan@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cranial Irradiation / adverse effects* Female Humans Immunoenzyme Techniques Keratin-1 Keratin-10 Keratin-14 Keratin-16 Keratin-6 Keratins / biosynthesis* Male Middle Aged Mucositis / etiology, metabolism*, pathology Radiation Injuries / metabolism* Radiotherapy Dosage Stomatitis / etiology, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/KRT1 protein, human; 0/KRT10 protein, human; 0/KRT14 protein, human; 0/KRT16 protein, human; 0/KRT6A protein, human; 0/KRT6B protein, human; 0/KRT6C protein, human; 0/Keratin-1; 0/Keratin-14; 0/Keratin-16; 0/Keratin-6; 147785-83-9/Keratin-10; 68238-35-7/Keratins |
| Comments/Corrections | |
Erratum In:
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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Nov;102(5):710 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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