Document Detail

Cytokeratin expression in initial oral mucositis of head and neck irradiated patients.
MedLine Citation:
PMID:  16448923     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this work was to study cytokeratin (Ck) expression in initial radiation-induced oral mucositis. STUDY DESIGN: Eleven cases of initial radiomucositis of the buccal mucosa and 9 normal specimens were immunostained for Ck 1, 5, 6, 7, 8, 10, 14, 16, 18, and 19 by immunoperoxidase method. RESULTS: Expression of Ck 1, 6, 10, and 16 was stronger in mucositis than in normal mucosa. Ck 7, 8, and 18 were negative for both control and study groups. Ck 5, 13, and 14 were positive for both groups, nevertheless suprabasal staining for Ck 14 was more evident in mucositis than in the control group. Sporadic staining for Ck 19 was observed in 1 case of mucositis and in 2 controls. CONCLUSIONS: Increased Ck expression can be associated with the reactive proliferation of the epithelium and increasing resistance of the oral mucosa during the initial phases of radiotherapy.
Paulo Rogério Ferreti Bonan; Estela Kaminagakura; Fábio Ramoa Pires; Pablo Agustin Vargas; Oslei Paes de Almeida
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Publication Detail:
Type:  Journal Article     Date:  2005-09-19
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  101     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-03-14     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  D; IM    
School of Dentistry, State University of Montes Claros, Minas Gerais, Brazil.
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MeSH Terms
Cranial Irradiation / adverse effects*
Immunoenzyme Techniques
Keratins / biosynthesis*
Middle Aged
Mucositis / etiology,  metabolism*,  pathology
Radiation Injuries / metabolism*
Radiotherapy Dosage
Stomatitis / etiology,  metabolism*,  pathology
Reg. No./Substance:
0/KRT1 protein, human; 0/KRT10 protein, human; 0/KRT14 protein, human; 0/KRT16 protein, human; 0/KRT6A protein, human; 0/KRT6B protein, human; 0/KRT6C protein, human; 0/Keratin-1; 0/Keratin-14; 0/Keratin-16; 0/Keratin-6; 147785-83-9/Keratin-10; 68238-35-7/Keratins
Erratum In:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Nov;102(5):710

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