Document Detail

Cytokeratin expression in human fetal tongue and buccal mucosa.
MedLine Citation:
PMID:  11022224     Owner:  NLM     Status:  MEDLINE    
Expression of cytokeratins (CK), a subset of intermediate filament (IF) proteins in epithelia, is developmentally regulated. CK expression may also change after malignant transformation. Our earlier studies on CK expression in human oral tumours and pre-cancerous lesions have shown specific changes in CK expression. We analysed CK expression in human tongue and buccal mucosa (BM) in fetuses in the embryonic age group of 16 to 27 weeks using biochemical and immunohistochemical techniques to find out whether there is any similarity in CK expression in human oral squamous cell carcinomas (SCC) and fetal oral tissues. CK 1, 8 and 18 were detected in a majority of samples using both techniques. Our earlier studies had shown aberrant expression of CK 1 and 18 in many of the oral SCC and leukoplakias. Studies by immunohistochemistry showed that these different CK antigens were expressed in different cell layers. CK 1(2) were present in the stratified epithelial layers whereas CK 8 and 18 were restricted to glandular epithelium. Till 27 weeks of gestation, both tongue and BM expressed CK 1, 8 and 18 along with CK 6 and 16. Thus, fetal tissues showed some similarities in CK pattern with their respective SCC.
M M Vaidya; S S Sawant; A M Borges; N K Naresh; M C Purandare; A N Bhisey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biosciences     Volume:  25     ISSN:  0250-5991     ISO Abbreviation:  J. Biosci.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-27     Completed Date:  2000-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100809     Medline TA:  J Biosci     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  235-42     Citation Subset:  IM    
Cancer Research Institute, Parel, Mumbai 400 012, India.
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MeSH Terms
Electrophoresis, Gel, Two-Dimensional
Fetal Proteins / biosynthesis*,  genetics
Fluorescent Antibody Technique, Indirect
Gene Expression Regulation, Developmental*
Gestational Age
Keratins / biosynthesis*,  genetics
Mouth Mucosa / embryology*,  metabolism,  ultrastructure
Protein Isoforms / biosynthesis*,  genetics
Tongue / embryology*,  metabolism,  ultrastructure
Reg. No./Substance:
0/Fetal Proteins; 0/Protein Isoforms; 68238-35-7/Keratins

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