Document Detail

Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst.
MedLine Citation:
PMID:  15006629     Owner:  NLM     Status:  MEDLINE    
Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature. Our aim was to assess the cytokeratin (CK) profile of central MEC and GOC, and compare the results with CK expression in salivary gland MEC and odontogenic cysts and tumors. Eighty-five cases, including 6 central MECs, 23 salivary gland MECs, 10 GOCs, 34 odontogenic cysts and 12 ameloblastomas, were studied through immunohistochemistry using eleven monoclonal anti-CK antibodies. All central MECs expressed CKs 5, 7, 8, 14, and 18 and all GOCs expressed CKs 5, 7, 8, 13, 14, and 19. Comparing CK expression from GOC and central MEC we found differences in CKs 18 (30% vs 100%) and 19 (100% vs 50%). Central MEC and GOC are probably distinct entities with CK profiles similar to lesions of glandular and odontogenic origins, respectively, and expression of CKs 18 and 19 could be useful in their differential diagnosis.
Fábio Ramôa Pires; Sow-Yeh Chen; Danyel Elias da Cruz Perez; Oslei Paes de Almeida; Luiz Paulo Kowalski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral oncology     Volume:  40     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, 157 Vila Isabel, CEP: 21550-030, Rio de Janeiro/RJ, Brazil.
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MeSH Terms
Carcinoma, Mucoepidermoid / chemistry*,  pathology
Immunohistochemistry / methods
Jaw Diseases / metabolism*,  pathology
Keratins / analysis*
Mandibular Diseases / metabolism,  pathology
Maxillary Diseases / metabolism,  pathology
Middle Aged
Odontogenic Cysts / chemistry*,  pathology
Salivary Gland Neoplasms / chemistry*,  pathology
Reg. No./Substance:

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