| Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma. | |
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MedLine Citation:
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PMID: 21036761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The clinical utility of tumour markers in pleural effusion is still controversial with regard to the efficient detection of malignant pleural mesothelioma (MPM). PATIENTS AND METHODS: The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) were retrospectively studied in pleural effusion of unknown origin in patients who had undergone medical thoracoscopy under local anaesthesia. RESULTS: The study included 134 patients (103 men and 31 women); among them, 33 had MPM. The level of pleural effusion CYFRA 21-1 and the CYFRA 21-1/CEA ratio were significantly different between MPM and other diseases (p<0.01). The sensitivity and specificity of the pleural effusion CYFRA 21-1/CEA ratio were 84.8% and 80.2%, respectively, when the CYFRA 21-1/CEA ratio cut-off value determined by receiver operating characteristic curve analysis was 19.1. CONCLUSION: MPM should be suspected when the CYFRA 21-1/CEA ratio in pleural effusion is greater than 19.1. |
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Authors:
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Hidekazu Suzuki; Tomonori Hirashima; Masashi Kobayashi; Shinji Sasada; Norio Okamoto; Nobuko Uehara; Motohiro Tamiya; Yuka Matsuura; Naoko Morishita; Ichiro Kawase |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 4343-6 Citation Subset: IM |
Affiliation:
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Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka, Japan. suzukih@ra.opho.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, Neoplasm / metabolism* Carcinoembryonic Antigen / metabolism* Female Humans Immunoassay Keratin-19 / metabolism* Luminescent Measurements Male Mesothelioma / metabolism*, pathology Pleural Effusion, Malignant / metabolism, pathology Pleural Neoplasms / metabolism*, pathology ROC Curve Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Keratin-19; 0/Tumor Markers, Biological; 0/antigen CYFRA21.1 |
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