Document Detail

Cytokeratin 10 and Ki-67 nuclear marker expression in keratoacanthoma and squamous cell carcinoma.
MedLine Citation:
PMID:  15588557     Owner:  NLM     Status:  MEDLINE    
The most frequent consideration in the clinical and histologic differential diagnosis of keratoacanthoma is squamous cell carcinoma. In the present study, cytokeratin 10 expression and proliferation rate as measured by Ki-67 expression were compared between 50 clinically and histologically diagnosed keratoacanthomas and 50 squamous cell carcinomas. Tissue sections from the skin were immunohistochemically stained with anti-cytokeratin 10 and anti-Ki-67 monoclonal antibodies. The distribution of cytokeratin 10 expression and proliferative cell count were analyzed. Study results showed higher cytokeratin 10 expression in keratoacanthomas than in squamous cell carcinomas and different distribution of staining in the two entities. The analysis of cytokeratin 10 expression showed a much wider range of values and statistically higher median (p<0.001) in keratoacanthomas than in squamous cell carcinomas. Additionally, the proliferation index of keratinocytes as measured by Ki-67 expression was significantly higher in squamous cell carcinomas than in keratoacanthomas (p<0.01). These results may prove helpful in histologic differentiation of these disorders.
Aleksandra Basta-Juzbasić; Sanja Klenkar; Jasminka Jakić-Razumović; Aida Pasić; Davorin Loncarić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  12     ISSN:  1330-027X     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-04-12     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia.
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MeSH Terms
Carcinoma, Squamous Cell / diagnosis,  metabolism*
Diagnosis, Differential
Keratins / metabolism*
Keratoacanthoma / diagnosis,  metabolism*
Ki-67 Antigen / metabolism*
Skin Neoplasms / diagnosis,  metabolism*
Reg. No./Substance:
0/Ki-67 Antigen; 68238-35-7/Keratins

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