Document Detail

Cytohistologic correlation of peritoneal washing cytology in gynecologic disease.
MedLine Citation:
PMID:  2728787     Owner:  NLM     Status:  MEDLINE    
The peritoneal washings and cul de sac aspirates from 204 patients undergoing 217 procedures for the evaluation of gynecologic disease were examined retrospectively and correlated with the histologic diagnoses. Of the 73 washings from patients with histologically benign genital disease, cytology diagnosed 64 (87.7%) as negative, 6 (8.2%) as inconclusive and 3 as malignant. One malignant washing was a true positive from a nongenital primary. False positives thus occurred in 2.7% of the benign cases on blind review. Of 144 cytologic examinations of washings from patients with histologically confirmed malignant disease of the female genital tract, 38 (26.4%) were considered positive after cytohistologic correlation. Four malignant cases (2.1%) were undercalled on blind review while 3 (2.0%) were considered overcalls. Eleven of 47 cases (23.4%) with biopsy-proven peritoneal disease had negative cytology after histologic correlation. Recurring problems in interpreting peritoneal washings included: (1) the differential diagnosis of the spectrum encompassed by reactive mesothelium, endosalpingiosis, borderline serous tumors and well-differentiated serous cystadenocarcinoma; (2) morphologic similarities between some tumor cells and mesothelial cells associated with treatment effects; and (3) a paucity of malignant cells in some washings, resulting in false-negative interpretations. Ineffective cytopreparation, particularly of bloody specimens, hampered interpretation of some specimens. Correlation with previous histology and cytology enhanced the accuracy of peritoneal washing cytology in this study.
R E Zuna; M L Mitchell; K A Mulick; W M Weijchert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  33     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1989 May-Jun
Date Detail:
Created Date:  1989-06-27     Completed Date:  1989-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-36     Citation Subset:  IM    
Department of Pathology, State University of New York, Stony Brook 11794-7025.
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MeSH Terms
Aged, 80 and over
Cervix Uteri / pathology
Endometrium / pathology
Genital Diseases, Female / diagnosis,  pathology*
Middle Aged
Ovary / pathology
Peritoneal Lavage*

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