Document Detail

Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway.
MedLine Citation:
PMID:  16702224     Owner:  NLM     Status:  MEDLINE    
Cytohesin binder and regulator (Cybr; also known as CYTIP, CASP, and PSCDBP) is a cytokine-induced gene preferentially expressed in hematopoietic tissues and in T helper 1 cells. Cybr protein associates with members of the cytohesin family, which are known ADP-ribosylation factors-GDP/GTP exchange factors, and its functions appear to regulate lymphocyte adhesion and cell-cell contact. Here we show that Cybr mRNA and protein levels are increased upon T cell receptor engagement. Cybr expression then influences T cell receptor-dependent signaling events, such as nuclear factor of activated T cells and AP-1 transcriptional activity. In addition, expression of Cybr results in increased T cell receptor-mediated activation of the Rho/Rac exchange factor Vav and of the JNK-p38 MAPK signaling pathway. The effects of Cybr on nuclear factor of activated T cells and AP-1 are dependent on MAPK activation, and enhanced activation of this cascade results in cooperation between the two transcription factors in the regulation of gene expression. These findings provide the first evidence that the adaptor protein Cybr not only regulates lymphocyte adhesion and cell-cell interaction but also contributes to the regulation of the signaling cascade and of the genetic program downstream of the T cell receptor.
Qian Chen; Alan Coffey; Sylvain G Bourgoin; Massimo Gadina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-15
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  281     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-17     Completed Date:  2006-09-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19985-94     Citation Subset:  IM    
Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.
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MeSH Terms
Cell Adhesion / immunology
Cell Communication
DNA Primers
DNA, Complementary / genetics
Gene Expression Regulation / immunology
Jurkat Cells
Lymphocyte Activation
MAP Kinase Kinase 4 / metabolism*
NFATC Transcription Factors / immunology,  metabolism
Receptors, Antigen, T-Cell / immunology*
Recombinant Proteins / immunology
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / immunology
T-Lymphocytes / immunology*
Th1 Cells / immunology
Transcription Factor AP-1 / metabolism*
Transcription Factors / genetics,  immunology*
Transcription, Genetic
Reg. No./Substance:
0/CYTIP protein, human; 0/DNA Primers; 0/DNA, Complementary; 0/NFATC Transcription Factors; 0/Receptors, Antigen, T-Cell; 0/Recombinant Proteins; 0/Transcription Factor AP-1; 0/Transcription Factors; EC Kinase Kinase 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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