Document Detail


Cytogenetics of a malignant ovarian germ-cell tumor.
MedLine Citation:
PMID:  9650555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and foci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.
Authors:
J van Echten; L C van Doorn; H C van der Linden; A Y van der Veen; C W Burger; B de Jong
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  77     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-17     Completed Date:  1998-07-17     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-8     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, University of Groningen, The Netherlands. J.van.Echten-Arends@Med.Rug.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneuploidy
Chromosome Aberrations*
Chromosomes, Human, Pair 12
Female
Germinoma / genetics*
Humans
Isochromosomes
Karyotyping
Ovarian Neoplasms / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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