Document Detail


Cytogenetics of human malignant melanoma and premalignant lesions.
MedLine Citation:
PMID:  6584203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosome studies were done on direct preparations, early passage cultures, and/or cell lines derived from melanocytic lesions of 17 patients. There were 5 nevi (3 dysplastic); 1 early primary melanoma (radial growth phase); 1 advanced primary melanoma (vertical growth phase) with multiple metastases; and 10 metastatic lesions. The 5 nevi had normal karyotypes, while each of the tumors had a predominantly abnormal karyotype. The early melanoma was pseudodiploid, including a 6p;22 translocation. Ten of the 11 advanced melanomas had one or more aberrations involving chromosome #1, with 9 having deletions or translocations of lp that involved the proximal segment 1p12----1p22 9 times in 8 lesions. Six advanced tumors had additional material involving 7q, including extra #7s (4 cases) and 7q+ (2 cases). Nine melanomas, including the early tumor, had alterations in chromosome #6. Three had additional copies of 6p (as iso6p or t6p); the others showed no consistent pattern. In one advanced tumor, the primary lesion and 5 metastases (removed seriatim over an 18-month period) had nearly identical karyotypes, indicating the clonal nature of the neoplasm. The nonrandom cytogenetic changes suggest that genes important in melanoma carcinogenesis are located on the proximal portion of 1p, on 7q, and on chromosome #6. More data on early lesions are needed to identify the relation of these various cytogenetic changes to the different stages of malignant melanoma development.
Authors:
G Balaban; M Herlyn; D Guerry; R Bartolo; H Koprowski; W H Clark; P C Nowell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  11     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Chromosome Aberrations*
Chromosome Banding
Chromosomes, Human, 1-3 / ultrastructure
Chromosomes, Human, 21-22 and Y
Chromosomes, Human, 6-12 and X
Genetic Markers
Humans
Karyotyping
Melanoma / genetics*
Nevus, Pigmented / genetics*
Precancerous Conditions / genetics*
Skin Neoplasms / genetics*
Translocation, Genetic
Grant Support
ID/Acronym/Agency:
CA-10815/CA/NCI NIH HHS; CA-25298/CA/NCI NIH HHS; CA-25874/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers

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