Document Detail

Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands.
MedLine Citation:
PMID:  1323949     Owner:  NLM     Status:  MEDLINE    
The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.
J Mark; R Dahlenfors; G Stenman; M Bende; I Melén
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  12     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1992 Jul-Aug
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1195-8     Citation Subset:  IM    
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
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MeSH Terms
Adenoma, Pleomorphic / genetics*,  pathology
Genetic Markers
Parotid Neoplasms / genetics*,  pathology
Salivary Gland Neoplasms / genetics*,  pathology
Salivary Glands, Minor*
Reg. No./Substance:
0/Genetic Markers

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