Document Detail

Cytogenetic studies on the nucleolar organizer region [NOR] activity in meningioma cells with normal and hypodiploid karyotypes.
MedLine Citation:
PMID:  7104986     Owner:  NLM     Status:  MEDLINE    
The association pattern and NOR silver staining of the acrocentric chromosomes was studied in normal and hypodiploid cell lines of four meningioma patients. In three cases the hypodiploid cells showed a more increased association frequency or NOR silver staining or both than the normal ones, indicating a compensatory mechanism between the NORs. Chromosomes #14 seemed to be more frequently involved in this phenomenon than other acrocentric chromosomes. From the silver staining results it was concluded that in meningioma cells, chromosomes #22 which bear active as well as inactive NORs were missing. The compensation between the NORs was probably only activated if an active NOR was lost.
H Zankl; H Huwer; K D Zang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  6     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
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MeSH Terms
Cell Line
Chromosome Deletion
Chromosomes, Human, 13-15
Chromosomes, Human, 21-22 and Y
Meningeal Neoplasms / genetics*
Meningioma / genetics*
Nucleolus Organizer Region / ultrastructure*

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