| Cytogenetic studies in women with primary amenorrhea. | |
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MedLine Citation:
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PMID: 2255934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytogenetic investigations were carried out on 117 women with primary amenorrhea who had been referred to our Genetics Laboratory by clinicians throughout Malaysia, after exclusion of other causes of the disorder. Thirty-six cases (31%) showed numerical or structural abnormalities of the sex chromosomes. These can be broadly classified into 4 main types, namely, presence of a Y chromosome (14%), X-chromosome aneuploidies (8%), structural anomalies of the X-chromosome (7%) and lastly, presence of a marker chromosome (2%). Mosaics constituted 17% of the abnormalities observed, always in association with a 45,X cell line. There was no observable correlation between the phenotype of the patients and their respective abnormal karyotypes. The aetiological role of sex chromosomal abnormalities in these amenorrheic women is discussed. |
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Authors:
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S K Ten; Y M Chin; P J Noor; K Hassan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Singapore medical journal Volume: 31 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1991-01-24 Completed Date: 1991-01-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 355-9 Citation Subset: IM |
Affiliation:
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Genetics Laboratory, Institute for Medical Research, Kuala Lumpur, Malaysia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amenorrhea / complications, genetics* Female Humans Karyotyping Sex Chromosome Aberrations / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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