Document Detail

Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis.
MedLine Citation:
PMID:  22077407     Owner:  NLM     Status:  In-Data-Review    
Ten types of bovine papillomavirus (BPV) have been described and there are reports of viral transmission via blood. The presence of viral DNA in lymphocytes was described to be associated with chromosome instability in these cells. This study presents an evaluation of chromosome instability in short-term peripheral lymphocyte cultures from cows presenting skin papillomatosis, compared with asymptomatic infected animals and non-infected healthy bovines. In a total of 2203 cells, 918 (42%) showed at least one chromosome aberration: 42.7 (±7.8) in animals with papillomatosis (BPV + W), 40.2 (±11) in asymptomatic animals (BPV - W) and 4 (±2) in control animals. Significant differences were found between the infected group (with or without symptoms) and the control group (P < 0.0001). The increased frequencies of chromosome aberrations suggest an interaction between the virus and host cell chromatin.
T C Melo; N Diniz; S R C Campos; O P Ferraz; C J Lindsey; T T Rieger; W Beçak; R C Stocco
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Publication Detail:
Type:  Journal Article     Date:  2011-03-15
Journal Detail:
Title:  Veterinary and comparative oncology     Volume:  9     ISSN:  1476-5829     ISO Abbreviation:  Vet Comp Oncol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185242     Medline TA:  Vet Comp Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brazil Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
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