Document Detail


Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis.
MedLine Citation:
PMID:  22077407     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ten types of bovine papillomavirus (BPV) have been described and there are reports of viral transmission via blood. The presence of viral DNA in lymphocytes was described to be associated with chromosome instability in these cells. This study presents an evaluation of chromosome instability in short-term peripheral lymphocyte cultures from cows presenting skin papillomatosis, compared with asymptomatic infected animals and non-infected healthy bovines. In a total of 2203 cells, 918 (42%) showed at least one chromosome aberration: 42.7 (±7.8) in animals with papillomatosis (BPV + W), 40.2 (±11) in asymptomatic animals (BPV - W) and 4 (±2) in control animals. Significant differences were found between the infected group (with or without symptoms) and the control group (P < 0.0001). The increased frequencies of chromosome aberrations suggest an interaction between the virus and host cell chromatin.
Authors:
T C Melo; N Diniz; S R C Campos; O P Ferraz; C J Lindsey; T T Rieger; W Beçak; R C Stocco
Related Documents :
21906097 - Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14 and 20 in norwegi...
405277 - A method for fate mapping the foci of lethal and behavioral mutants in drosophila melan...
8096827 - Refined linkage map of chromosome 5 in the region of the spinal muscular atrophy gene.
8128967 - Use of genetic and physical mapping to locate the spinal muscular atrophy locus between...
6945287 - Human inherited marker chromosome 22 short-arm enlargement: investigation of rdna gene ...
18620557 - The hypocrea jecorina (trichoderma reesei) hypercellulolytic mutant rut c30 lacks a 85 ...
Publication Detail:
Type:  Journal Article     Date:  2011-03-15
Journal Detail:
Title:  Veterinary and comparative oncology     Volume:  9     ISSN:  1476-5829     ISO Abbreviation:  Vet Comp Oncol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185242     Medline TA:  Vet Comp Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brazil Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Single-agent gemcitabine chemotherapy in dogs with hepatocellular carcinomas.
Next Document:  Phase I/II clinical trial of 2-difluoromethyl-ornithine (DFMO) and a novel polyamine transport inhib...