Document Detail


Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia.
MedLine Citation:
PMID:  1550774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic studies of bone marrow fibroblasts and blood cells from peripheral blood or bone marrow were performed in 19 patients with myelofibrosis with myeloid metaplasia (group 1), nine patients with other myeloproliferative syndromes without myelofibrosis (group 2), and 12 patients with anaemia secondary to iron deficiency or chronic inflammatory disease (group 3). Clonal cell populations with abnormal karyotypes were seen in the bone marrow or blood in five of 14 (36%) group 1 patients, one of nine (11%) group 2 patients and none (0%) of the group 3 patients. Abnormal karyotypes of bone marrow fibroblasts were found in three of 16 (19%) of patients of group 1, and in two of nine (22%) and two of 12 (17%) patients each of groups 2 and 3, respectively. Since abnormal karyotypes can be found in bone marrow fibroblasts cultured from normal subjects, and since the abnormalities seen in the bone marrow fibroblasts differed from those found in bone marrow or blood cells, it is suggested that abnormal karyotypes found in bone marrow fibroblasts cultured from patients with primary myelofibrosis do not necessarily reflect neoplasia. The results of this study are compatible with the widely accepted hypothesis that in patients presenting with 'primary' myelofibrosis, the fibrosis is a secondary reactive process.
Authors:
J C Wang; H D Lang; S Lichter; M Weinstein; P Benn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  80     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-27     Completed Date:  1992-04-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM    
Affiliation:
SUNY Health Science Center, Brookdale Hospital Medical Center, Department of Hematology and Oncology, Brooklyn.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Blood Cells / pathology
Bone Marrow / pathology*
Chromosome Aberrations / genetics*
Chromosome Disorders
Female
Fibroblasts / pathology
Humans
Male
Middle Aged
Primary Myelofibrosis / complications,  etiology,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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