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Cytogenetic and molecular genetic study on glioblastoma arising in granular cell astrocytoma: a case report.
MedLine Citation:
PMID:  22204711     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Granular cell astrocytoma is a rare infiltrative malignant glioma with prominent granular cell change. Granular cell astrocytomas are biologically aggressive compared with conventional infiltrating astrocytomas of similar grades, but their genetic alterations are poorly known. We report a case of glioblastoma arising in granular cell astrocytoma and its genetic and molecular features. Histologically, the tumor not only showed features typical of granular cell astrocytoma but also demonstrated frequent mitoses, pseudopalisading necrosis, and vascular endothelial hyperplasia, compatible with glioblastoma. Array-based comparative genomic hybridization and focused molecular genetic analyses demonstrated gain of chromosome 7; losses of chromosome 1p, 8p, 9p, 10, 13q, and 22q; amplification of epidermal growth factor receptor (EGFR); and homozygous deletion of CDKN2A as well as isocitrate dehydrogenase 1 (IDH1) mutation and MGMT promoter methylation. Our results indicate that glioblastomas arising in granular cell astrocytoma share common molecular genetic features with conventional glioblastoma; however, the coexistence of EGFR amplification, homozygous deletion of CDKN2A, loss of chromosome 10, and IDH1 mutation seems to be unique.
Authors:
Mee Joo; Sung-Hye Park; Sun Hee Chang; Hanseong Kim; Chan-Young Choi; Chae-Heuck Lee; Byung Hoon Lee; Yoon Joon Hwang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-26
Journal Detail:
Title:  Human pathology     Volume:  -     ISSN:  1532-8392     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 411-706, Republic of Korea.
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