| Cytogenetic and immunoglobulin markers of human leukemic B-cell lines. | |
MedLine Citation:
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PMID: 406986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes the establishment of two permanent leukemic B-cell lines (BALM-1 and -2) originating from the blood cells of a patient with a B-cell type of acute lymphoblastic leukemia. The cells of BALM-1 and -2 exhibited cell surface markers compatible with B-cell origin. The identity between the leukemic cells in vivo and those of the BALM lines was established on the basis of the karyotypic picture, including marker chromosomes 14q+ and t(12;17;?) and cell surface immunoglobulins (K, delta, and mu chain determinants). |
Authors:
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J Minowada; M Oshimura; T Tsubota; D J Higby; A A Sandberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 37 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-09-29 Completed Date: 1977-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3096-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm B-Lymphocytes / immunology*, ultrastructure Cell Line Chromosome Aberrations* Chromosomes / ultrastructure Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X Humans Immunoglobulin D Immunoglobulin M Immunoglobulin delta-Chains Immunoglobulin kappa-Chains Immunoglobulin mu-Chains Leukemia, Lymphoid / genetics*, immunology* Neoplasms, Experimental / genetics, immunology Receptors, Antigen, B-Cell* Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Immunoglobulin D; 0/Immunoglobulin M; 0/Immunoglobulin delta-Chains; 0/Immunoglobulin kappa-Chains; 0/Immunoglobulin mu-Chains; 0/Receptors, Antigen, B-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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