Document Detail

Cytogenetic and immunoglobulin markers of human leukemic B-cell lines.
MedLine Citation:
PMID:  406986     Owner:  NLM     Status:  MEDLINE    
This study describes the establishment of two permanent leukemic B-cell lines (BALM-1 and -2) originating from the blood cells of a patient with a B-cell type of acute lymphoblastic leukemia. The cells of BALM-1 and -2 exhibited cell surface markers compatible with B-cell origin. The identity between the leukemic cells in vivo and those of the BALM lines was established on the basis of the karyotypic picture, including marker chromosomes 14q+ and t(12;17;?) and cell surface immunoglobulins (K, delta, and mu chain determinants).
J Minowada; M Oshimura; T Tsubota; D J Higby; A A Sandberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  37     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-09-29     Completed Date:  1977-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3096-9     Citation Subset:  IM    
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MeSH Terms
Antigens, Neoplasm
B-Lymphocytes / immunology*,  ultrastructure
Cell Line
Chromosome Aberrations*
Chromosomes / ultrastructure
Chromosomes, Human, 13-15
Chromosomes, Human, 16-18
Chromosomes, Human, 6-12 and X
Immunoglobulin D
Immunoglobulin M
Immunoglobulin delta-Chains
Immunoglobulin kappa-Chains
Immunoglobulin mu-Chains
Leukemia, Lymphoid / genetics*,  immunology*
Neoplasms, Experimental / genetics,  immunology
Receptors, Antigen, B-Cell*
Translocation, Genetic
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Immunoglobulin D; 0/Immunoglobulin M; 0/Immunoglobulin delta-Chains; 0/Immunoglobulin kappa-Chains; 0/Immunoglobulin mu-Chains; 0/Receptors, Antigen, B-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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