Document Detail


Cytogenetic follow-up after allogeneic bone-marrow transplantation for Ph1-positive chronic myelogenous leukemia.
MedLine Citation:
PMID:  2310876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial cytogenetic studies were carried out on 36 patients with Ph1-positive chronic myelogenous leukemia treated with allogeneic bone-marrow transplantation from unlike sex (21 patients) or like sex (15 patients) donors. Fourteen of the 21 sex-mismatched and 12 of the 15 sex-matched donor marrows were T cell depleted. Disease relapse was documented in 19 of the 26 patients who received T cell-depleted marrow, and in none of the 10 patients who received non-T cell-depleted marrow. In the group of patients with unlike sex donor, a triple donor/normal recipient/Ph1-positive recipient or a double donor/Ph1-positive recipient chimerism was documented during the subsequent months, while on alpha-interferon treatment for relapse. Two of these patients subsequently showed a complete disappearance of the Ph1 chromosome. Unstable and/or stable, clonal or non-clonal chromosome changes were detected in Ph1-positive cells from 12 of the 19 patients who relapsed. Analysis of the identified stable changes showed a non-random distribution of breakpoints with clustering to chromosome nos. 1, 4, 7 and 12.
Authors:
G Alimena; M R De Cuia; C Mecucci; W Arcese; F Mauro; M Screnci; M Mancini; M Cedrone; M Nanni; E Montefusco
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  5     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-20     Completed Date:  1990-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Affiliation:
Department of Human Biopathology, University of Rome La Sapienza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Marrow Transplantation*
Child
Chimera / genetics
Chromosome Aberrations / genetics
Chromosome Disorders
Female
Follow-Up Studies
Graft vs Host Disease / prevention & control
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy,  genetics*,  surgery
Lymphocyte Depletion
Male
Middle Aged
Remission Induction / methods
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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