Document Detail


Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia.
MedLine Citation:
PMID:  14697644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report cytogenetic results in a series of 60 patients affected with multiple myeloma (MM) and plasma cell leukemia (PCL) and compare the results with those previously reported. In our series, a total of 41% of MM patients and 71% of PCL patients displayed chromosome abnormalities. To evaluate the clinical value of monosomy 18, we obtained fluorescence in situ hybridization results (using centromeric probe for chromosome 18) of 22 MM patients who displayed a normal karyotype. Monosomy 18 was present in 3 of 22 patients (14%). Using conventional cytogenetics, we detected monosomy 18 in one patient affected with PCL. Two of four cases with monosomy 18 followed an aggressive course, with overall survival of 1 and 9 months. The remaining two are in follow-up and remain stable. The association of monosomy 18 with IgA subtype predominance and poor prognosis was not observed in this series of MMs and PCLs. Although these results do not confirm our previous hypothesis, further observations of this group of patients (with monosomy 18) regarding malignant transformation is warranted.
Authors:
Elisabet Lloveras; Isabel Granada; Lurdes Zamora; Blanca Espinet; Lourdes Florensa; Carles Besses; Marisol Xandri; Maria Encarnación Pérez-Vila; Fuensanta Millà; Soledad Woessner; Francesc Solé
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  148     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Affiliation:
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar-IMAS, Passeig marítim 25-29, 08003 Barcelona, Spain. e0037@imas.imim.es
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MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations*
Chromosomes, Human, Pair 18
Humans
In Situ Hybridization, Fluorescence / methods*
Karyotyping
Leukemia, Plasma Cell / genetics*
Monosomy
Multiple Myeloma / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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