Document Detail


Cytogenetic and flow cytometric studies of cells from patients with Fanconi's anemia.
MedLine Citation:
PMID:  7116934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells from patients wtih Fanconi's anemia are unusually sensitive to agents which are capable of crosslinking DNA. This increased sensitivity can be detected both by cytogenetic and flow cytometric methods. An elevated frequency of chromosome aberrations, which is further exaggerated by exposure of cells to DNA crosslinking agents, is a general feature of Fanconi's anemia. Information about the formation of sister chromatid exchanges in this disease is less consistent. Cytogenetic analysis of cells from patients with Fanconi's anemia can be compromised by a low mitotic index. This is reflected in an accumulation of cells In the G2 phase of the cycle, after exposure to the bifunctional alkylating agent, mitomycin C. New methods for differentiating individuals with Fanconi's anemia from unaffected individuals should be of empirical use and might also facilitate mechanistic studies of this disease.
Authors:
S A Latt; T N Kaiser; A Lojewski; C Dougherty; L Juergens; S Brefach; E Sahar; K Gustashaw; R R Schreck; M Powers; M Lalande
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  33     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Aplastic / genetics*
Cell Cycle
Chromosome Aberrations
DNA / metabolism
DNA Repair
Fanconi Anemia / genetics*,  metabolism
Humans
Sister Chromatid Exchange
Grant Support
ID/Acronym/Agency:
GM-21121/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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