Document Detail


Cytogenetic findings in adult de novo acute myeloid leukaemia. A population-based study of 303/337 patients.
MedLine Citation:
PMID:  14531903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a 10-year period (1992-2001) in the region of Southern Denmark, 337 patients aged 15 years or older (range 16-93 years, median 67 years) were diagnosed with acute myeloid leukaemia (AML). Cytogenetic analysis was carried out in 90%, of whom 53% had clonal chromosome aberrations. Some 24% and 31% had only numerical or structural abnormalities respectively. The remaining patients showed both types of abnormalities. Ploidy levels in decreasing order were: pseudodiploidy, 41%; hyperdiploidy, 32%; and hypodiploidy, 27%. Pseudodiploidy characterizes type M3 (70%) and hypodiploidy M6 (56%). Recurrent cytogenetic abnormalities--t(8;21), t(15;17) and inv(16)--were found in 3.3%, 3.3% and 2.0% of all patients respectively. Prognostically intermediate and adverse aberrations were found in 39% and 44%, respectively, of those with an abnormal karyotype. Rare recurrent aberrations were found in two patients in this material. A previously described non-recurrent abnormality was found to be recurrent in one patient [der(20)t(11;20)(q13.2;p13)]. New, previously undescribed abnormalities were found in 41 patients. Statistically significant correlations were found between t(15;17) and young age (P < 0.001), inv(16) and young age (P < 0.006), -17 and M6 (P = 0.007), and M6 and complex karyotype with five or more unrelated aberrations (P = 0.004). We conclude that this truly population-based cytogenetic study of adult AML showed distributions of chromosome abnormalities that differ from those described so far.
Authors:
Birgitte S Preiss; Gitte B Kerndrup; Kai G Schmidt; Anne G Sørensen; Niels-Aage T Clausen; Ole V Gadeberg; Torben Mourits-Andersen; Niels T Pedersen;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  123     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-08     Completed Date:  2003-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-34     Citation Subset:  IM    
Affiliation:
Institute of Pathology, Odense University Hospital, Denmark. birgitte.preiss@ouh.fyns-amt.dk
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Chromosome Aberrations*
Denmark / epidemiology
Female
Genomics
Humans
Incidence
Karyotyping
Leukemia, Myeloid / epidemiology,  genetics*
Male
Middle Aged
Ploidies
Prognosis
Translocation, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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