| Cytogenetic findings in 1250 chorionic villus samples obtained in the first trimester with clinical follow-up of the first 1000 pregnancies. | |
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MedLine Citation:
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PMID: 2803989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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First-trimester chorionic villus sampling (CVS) was performed in a series of 1250 pregnancies. The direct method of karyotyping was successful in 1205 (96.4%). Abnormal laboratory findings resulted in 60 terminations of pregnancy (4.8%). In addition, six unexpected balanced chromosome rearrangements were detected. False-positive cytogenetic findings occurred in 2.3%, comprising 22 with mosaicism confined to the trophoblast, and a further six non-mosaic false-positive discrepancies were detected, four after termination of pregnancy. The outcome of the first 1000 pregnancies is known in all but one. There were no false-negative findings. Of 947 pregnancies meant to be continued, 34 (3.6%) ended in pregnancy loss before 28 weeks gestation. However, obstetricians with an experience of over 150 procedures had a pregnancy loss of 1.3%. |
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Authors:
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N J Leschot; H Wolf; A C Van Prooijen-Knegt; C J van Asperen; M Verjaal; G H Schuring-Blom; K Boer; H H Kanhai; G C Christiaens |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 96 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-11-28 Completed Date: 1989-11-28 Revised Date: 2004-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 663-70 Citation Subset: AIM; IM; J |
Affiliation:
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University of Amsterdam, Academic Medical Centre, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Villi Sampling* Chromosome Aberrations* / diagnosis* Chromosome Banding Chromosome Disorders* False Positive Reactions Female Follow-Up Studies Humans Karyotyping Maternal Age Pregnancy Pregnancy Complications / diagnosis* Pregnancy, High-Risk |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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