Document Detail

Cytogenetic findings in 1250 chorionic villus samples obtained in the first trimester with clinical follow-up of the first 1000 pregnancies.
MedLine Citation:
PMID:  2803989     Owner:  NLM     Status:  MEDLINE    
First-trimester chorionic villus sampling (CVS) was performed in a series of 1250 pregnancies. The direct method of karyotyping was successful in 1205 (96.4%). Abnormal laboratory findings resulted in 60 terminations of pregnancy (4.8%). In addition, six unexpected balanced chromosome rearrangements were detected. False-positive cytogenetic findings occurred in 2.3%, comprising 22 with mosaicism confined to the trophoblast, and a further six non-mosaic false-positive discrepancies were detected, four after termination of pregnancy. The outcome of the first 1000 pregnancies is known in all but one. There were no false-negative findings. Of 947 pregnancies meant to be continued, 34 (3.6%) ended in pregnancy loss before 28 weeks gestation. However, obstetricians with an experience of over 150 procedures had a pregnancy loss of 1.3%.
N J Leschot; H Wolf; A C Van Prooijen-Knegt; C J van Asperen; M Verjaal; G H Schuring-Blom; K Boer; H H Kanhai; G C Christiaens
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  96     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-11-28     Completed Date:  1989-11-28     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  AIM; IM; J    
University of Amsterdam, Academic Medical Centre, The Netherlands.
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MeSH Terms
Chorionic Villi Sampling*
Chromosome Aberrations* / diagnosis*
Chromosome Banding
Chromosome Disorders*
False Positive Reactions
Follow-Up Studies
Maternal Age
Pregnancy Complications / diagnosis*
Pregnancy, High-Risk

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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