Document Detail

Cytogenetic effects of an agricultural antibiotic, captan, on mouse bone marrow and testicular cells.
MedLine Citation:
PMID:  3608938     Owner:  NLM     Status:  MEDLINE    
This paper deals with the cytogenetic effects of Captan on mouse bone marrow and testis. We used (a) the assays of micronuclei (MN) in polychromatic erythrocytes (PCE), (b) the mouse chromosomal aberration test on bone marrow and testis, and (c) the assay of sperm morphology. The tested doses in these assays were 1000, 800, 400, 100, and 50 mg/kg. The results showed that Captan was remarkably mutagenic to bone marrow, the lowest dose inducing MN being 100 mg/kg, and to chromosome breakage, 400 mg/kg. It was also demonstrated that captan was mutagenic to cells of the mouse testis; there was a certain relationship between dosage and response. The lowest doses inducing mutagenicity of spermatocyte and primary spermatogonia and sperm-head abnormality were 50, 800, and 200 mg/kg, respectively.
J Y Feng; B Y Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  43     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-18     Completed Date:  1987-09-18     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / drug effects,  pathology*
Captan / toxicity*
Chromosome Aberrations*
Spermatozoa / drug effects
Testis / drug effects,  pathology*
Reg. No./Substance:
0/Mutagens; 133-06-2/Captan

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